Dear All,
The wheels of science grind very slowly. Finally, the first half of the work that was the subject
of Jennifer Luke's Ph.D. thesis; presentation in Bellingham, Washington (ISFR conference) in
1998 and a videotaped interview I had with her (see www.fluoridealert.org/videos.htm), has
been published in Caries Research (see abstract below).

In my view this work is of enormous importance and could be (or should be) the scientific
straw that breaks the camel's back of fluoridation. Many of our subscribers are familiar with
the details but let me repeat them here.

When Luke found out that the pineal gland - a little gland in the center of the brain,
responsible for a very large range of regulating activities (it produces serotonin and
melatonin) - was also a calcifying tissue, like the teeth and the bones, she hypothesized it
would concentrate fluoride to very high levels. The gland is not protected by the blood brain rate of blood, second only to the Luke had 11 cadavers analyzed in the UK. As she predicted she found astronomically high levels of fluoride in the calcium hydroxy apatite crystals produced by the gland. The average was 9000 ppm and went as high as 21,000 in one case. These levels are at, or higher, than fluoride levels in the bones of people suffering from skeletal
fluorosis. It is these findings which have just been published. It is the ramifications of these findings which have yet to be published. In the second half of her work she treated animals (Mongolian gerbils) with fluoride at a crack pineal gland research unit at the University of Surrey, UK (so there is no question about the quality of this work). She found that melatonin production (as measured by the concentration of a melatonin metabolite in the urine) was lower in the animals treated with high fluoride levels compared with those treated with low levels. Luke hypothesizes that one of the four enzymes needed to convert the amino acid tryptophan (from the diet) into melatonin is being inhibited by fluoride. It could be one of the two enzymes which convert tryptophan to serotonin or one of the two which convert
serotonin to melatonin. Significance? Huge. Melatonin is responsible for regulating all kinds of
activities and there is a vast amount of work investigating its possible roles in aging, cancer
and many other life processes.

The one activity that Luke is particularly interested in is the onset of puberty. The highest levels of melatonin ( produced only at night) is generated in young children. It is thought that it is the fall of these melatonin levels which acts like a biological clock and triggers the onset of puberty. In her gerbil study she found that the high fluoride treated animals were reaching puberty earlier than the low fluoride ones. We know from recent studies - and considerable press coverage - that young girls are reaching puberty earlier and earlier in the U.S. Luke is not saying that fluoride (or fluoridation) is the cause but her work waves a very worrying red flag. Fluoride's role in earlier puberty needs more thorough investigation. Of an interesting historical note, in the Newburgh versus Kingston fluoridation trial (1945-1955), it was found that the girls in fluoridated Newburgh were reaching menstruation, on average, five months earlier than the girls in unfluoridated Kingston, but the result was not thought to be significant at the time (Schlessinger et al, 1956).

When one considers the seriousness of a possible interference by fluoride on a growing
child's pineal gland (and for that matter, elderly pineal glands) it underlines the recklessness
of fluoridation. The precautionary principle would say, as would basic common sense, that
you don't take these kind of risks with our children for a benefit which, at best, amounts to 0.6
tooth surfaces out of 128 tooth surfaces in a child's mouth (Brunelle and Carlos, 1990, Table
6).

I have a copy of Luke's Ph.D. thesis and would be willing to share it with those who have a
serious scientific interest in this issue. The other references cited above can be found in my
Statement of Concern which is published on the FAN webpage: http://www.fluoridealert.org/fluoride-statement.htm Paul Connett Paper :

Original Paper
Citation : Caries Res 2001;35:125-128
Title : Fluoride Deposition in the Aged Human Pineal Gland Author(s): J. Luke
Info : Figures: 2; Tables: 0; References: 32 Keywords : Calcium; Distribution; Fluoride; Human pineal gland; Hydroxyapatite; Pineal concretions Abstract : The purpose was to discover whether fluoride (F) accumulates in the aged human pineal gland. The aims were to determine (a) F-concentrations of the pineal gland (wet), corresponding muscle (wet) and bone (ash); (b) calcium-concentration of the pineal. Pineal, muscle and bone were dissected from 11 aged cadavers and assayed for F using the HMDS-facilitated diffusion, F-ion-specific electrode method. Pineal calcium was determined using atomic absorption spectroscopy. Pineal and muscle contained 297+/-257 and 0.5+/-0.4 mg F/kg wet weight, respectively; bone contained 2,037+/-1,095 mg F/kg ash weight. The pineal contained 16,000+/-11,070 mg Ca/kg wet weight. There was a positive correlation between pineal F and pineal Ca (r = 0.73, p<0.02) but no correlation between pineal F and bone F. By old age, the pineal gland has readily accumulated F and its F/Ca ratio is higher than bone.


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